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Updated: Aug 20, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Amyotrophic lateral sclerosis with dementia
1Neurological Department, University of Modena, Italy.
Abstract:
Four patients with amyotrophic lateral sclerosis (ALS) and dementia are reported. Mental symptoms antedated motor signs and were investigated with a neuropsychology battery, which brought out different patterns of cognitive impairment. A case presented with frontal dementia, another with a predominant aphasic, apraxic, amnesic syndrome, while the remainders showed cognitive decline in association with blunt affect. Motor signs were characterized by a precocious involvement of the upper motor system.
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