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Related Experiment Videos

Decrease in normal human corneal sensitivity with topical diclofenac sodium

K Szerenyi1, K Sorken, J J Garbus

  • 1Doheny Eye Institute, University of Southern California School of Medicine, Los Angeles 90033.

American Journal of Ophthalmology
|September 15, 1994
PubMed
Summary

Topical diclofenac sodium significantly reduces human corneal sensitivity. This effect, observed with repeated applications, returned to baseline within an hour after discontinuing the drug.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Neuroscience

Background:

  • Corneal sensitivity is crucial for ocular surface health and protective reflexes.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) are used in ophthalmology, but their effects on corneal sensation require detailed investigation.

Purpose of the Study:

  • To evaluate the impact of topical diclofenac sodium on human corneal sensitivity.
  • To compare the effects of diclofenac sodium with its vehicle control on corneal sensation.

Main Methods:

  • A prospective study involving ten adult subjects.
  • Corneal sensitivity was measured using the Cochet-Bonnet esthesiometer.
  • Diclofenac sodium 0.1% and its vehicle were administered unilaterally, with repeated applications over 20 minutes and subsequent measurements until baseline recovery.

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Main Results:

  • Diclofenac sodium significantly decreased corneal sensitivity in all subjects (P = .0001) compared to the vehicle.
  • The reduction in sensitivity was dose-dependent, increasing with repeated drug administration.
  • Corneal sensitivity returned to baseline levels within one hour after cessation of diclofenac sodium application.

Conclusions:

  • Topical diclofenac sodium substantially reduces sensitivity in normal, unoperated human corneas.
  • The vehicle control demonstrated no measurable effect on corneal sensitivity.
  • Diclofenac sodium's effect on corneal sensitivity is significant but transient.