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Updated: Jul 30, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

[The diagnosis and prevention of parenterally transmitted viral infections]

T V Golosova, A V Somova

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |October 1, 1993
    PubMed

    Insights

    This study investigated viral markers in blood donors and high-risk individuals. Hepatitis C virus antibodies were frequently detected in specific patient groups and drug addicts, with regional variations observed.

    Area of Science:

    • Virology
    • Infectious Diseases
    • Public Health

    Background:

    • Blood and plasma donors, along with individuals at high risk for infections, are routinely screened for viral pathogens.
    • Previous studies have indicated varying prevalence rates of viral infections across different populations and geographical regions.

    Purpose of the Study:

    • To determine the prevalence of antibodies to Human Immunodeficiency Virus types 1 and 2 (HIV-1/2), Human T-Lymphotropic Virus type 1 (HTLV-1), and markers for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV).
    • To assess the detection rates in blood/plasma donors and individuals with high-risk exposure.
    • To compare the performance of two commercial test systems for anti-HCV detection.

    Main Methods:

    • Serological testing for antibodies to HIV-1/2, HTLV-1, HBV markers, and anti-HCV.
    • Analysis of detection rates in various donor groups (general, reserve) and high-risk populations (hematological patients, hemodialysis patients, drug addicts, medical personnel).
    • Regional prevalence data collection for anti-HCV.
    • Comparative evaluation of sensitivity and specificity for two commercial anti-HCV test systems (Ortho, USA and Organon, Holland).

    Main Results:

    • A high prevalence of anti-HCV was found in donors with elevated serum enzymes, hematological patients, hemodialysis patients, and drug addicts.
    • Significant detection rates of HBV markers were observed in hematological patients and medical personnel in hematological and surgical clinics.
    • Approximately 45% of reserve donors showed at least one HBV marker.
    • Regional anti-HCV detection rates varied: 1-3% in Baltic countries, 2-5% in Russia, 5-7% in Middle Asia, and 8-12% in Moldova.
    • The sensitivity and specificity of the Ortho and Organon anti-HCV test systems were comparable.

    Conclusions:

    • Hepatitis C virus poses a significant detection challenge in specific high-risk populations and certain geographical regions.
    • Hepatitis B virus markers are prevalent among hematological patients and healthcare workers, necessitating continued vigilance.
    • The evaluated commercial test systems demonstrate reliable performance for anti-HCV detection.

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