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Related Experiment Videos

Ulcerative colitis in apes: A comparison with the human disease

G B Scott, I F Keymer

    The Journal of Pathology
    |April 1, 1975
    PubMed
    Summary

    Diarrhea in apes led to fatal colon pathology. Researchers found these changes resembled human ulcerative colitis, suggesting apes may serve as animal models for this disease.

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    Area of Science:

    • Veterinary Pathology
    • Primate Medicine
    • Gastroenterology

    Background:

    • Diarrhea is a common and potentially fatal condition in captive primates.
    • Ulcerative colitis (UC) is a chronic inflammatory bowel disease in humans with unclear etiology.
    • Apes, as close relatives to humans, may develop similar pathologies.

    Purpose of the Study:

    • To describe the pathological colonic changes in two gorillas and one orang-utan that died from diarrhea.
    • To evaluate the potential of these cases as examples of ulcerative colitis in apes.
    • To discuss the suitability of apes and monkeys as animal models for human ulcerative colitis.

    Main Methods:

    • Necropsy and histopathological examination of colons from affected apes.
    • Microscopic analysis to identify inflammatory patterns and tissue damage.
    • Comparison of observed pathological changes with established criteria for human ulcerative colitis.

    Main Results:

    • Pathological changes in the colons of the affected apes were observed.
    • No specific causative agents were identified in these cases.
    • The observed colonic changes were indistinguishable from the active phase of ulcerative colitis in humans.
    • Evidence of early healing was noted in one of the cases.

    Conclusions:

    • The described cases in apes are considered potential examples of ulcerative colitis.
    • Apes and monkeys may serve as valuable animal models for studying human ulcerative colitis.
    • Further research is warranted to explore the use of these species in understanding UC pathogenesis and treatment.

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