Changes in physical symptoms, blood pressure and quality of life over 30 days

The existence of subjective symptoms arising from high blood pressure (BP) remains controversial. Few studies have been performed which compare symptoms of hypertensives and normotensives. The results of these studies are inconsistent. The present study investigates the intensities and prevalences of symptoms of hypertensives and normotensives and the relationship between symptoms and BP for both groups. During a 30-day period, 45 patients with primary hypertension and 45 normotensive controls documented BPs and intensities of 13 symptoms daily as well as mood and life satisfaction weekly. Starting on day 3 hypertensives received beta-blocker therapy (bopindolol, 1 mg/day). The BP values of the hypertensives normalized during the study, while the BPs of the normotensives did not change. At the beginning, hypertensives showed higher prevalences and intensities of the symptoms and poorer mood and life satisfaction. After normalization of BP, hypertensives attained scores similar to those of normotensives in all measured categories. Calculating within-S correlations between symptom intensities and systolic BPs, 70% of the hypertensives, but only 27% of the normotensives, showed at least one significant correlation. The differences observed between untreated hypertensives and the normotensive control group with respect to the prevalence and intensity of symptoms provide convincing evidence that untreated hypertensives are by no means symptom-free. The within-S correlations of the present study documented well the close relationship between symptoms and actual BP for a percentage of hypertensives.