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Neurotoxicity of immunotoxins
O Ilercil1, D W Laske, S Walbridge
1Biochemistry Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
Molecular and Chemical Neuropathology
|February 1, 1994
Abstract:
Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to prevent or minimize this toxicity in future clinical trials.