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Related Experiment Videos

Hepatitis C virus: historical perspective and current concepts

R H Purcell1

  • 1Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

FEMS Microbiology Reviews
|July 1, 1994
PubMed
Summary

Hepatitis C virus (HCV) has become a significant public health concern. While blood-product transmission is controlled, community-acquired HCV remains a major medical challenge.

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A survey of zoonotic pathogens carried by Norway rats in Baltimore, Maryland, USA.

Epidemiology and infection·2007

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis C has evolved from an unknown entity to a major public health issue over 30 years.
  • The hepatitis C virus (HCV), a Flaviviridae family member, causes about 20% of clinical viral hepatitis in the U.S.

Purpose of the Study:

  • To review the progress in understanding hepatitis C.
  • To highlight the challenges in controlling community-acquired hepatitis C.

Main Methods:

  • Review of scientific literature on hepatitis C.
  • Analysis of public health data regarding hepatitis C transmission and control.

Main Results:

  • Significant advancements in understanding HCV followed its molecular characterization.
  • Control of HCV transmission in blood products has been highly successful.

Conclusions:

  • Hepatitis C virus (HCV) is a significant cause of viral hepatitis in the United States.
  • While bloodborne transmission is largely controlled, preventing community-acquired hepatitis C presents a substantial challenge for medical and scientific communities.

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