Related Experiment Videos
Steroid response pattern in Indian children with nephrotic syndrome
1Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Acta Paediatrica (Oslo, Norway : 1992)
|May 1, 1994
Summary
Steroid response in childhood nephrotic syndrome varies. Factors like older age, male sex, and specific histopathology predict poor response to prednisolone, guiding treatment decisions.
Area of Science:
- Pediatric Nephrology
- Clinical Medicine
Background:
- Steroid response is crucial for managing childhood nephrotic syndrome.
- Limited data exists on clinical, biochemical, and histopathological profiles across steroid response categories in the local context.
Purpose of the Study:
- To analyze the clinical, biochemical, and histopathological characteristics of children with nephrotic syndrome based on their steroid response.
- To identify factors predicting poor response to standard prednisolone therapy.
Main Methods:
- A study of 127 children with nephrotic syndrome treated with oral prednisolone (APN protocol).
- Classification into steroid response categories (infrequent relapsers, frequent relapsers, steroid-dependent, initial non-responders, subsequent non-responders) based on follow-up.
- Analysis of clinical, biochemical, and histopathological data.
Main Results:
- Infrequent relapsers were the most common steroid response category (37.9%) among 116 children with >6 months follow-up.
- Other categories included frequent relapsers (21.6%), steroid-dependent (18.1%), initial non-responders (17.3%), and subsequent non-responders (5.1%).
- Predictors of poor prednisolone response included age >8 years, male sex, hypertension, microscopic hematuria, and non-minimal change disease on biopsy.
Conclusions:
- Steroid response patterns are diverse in childhood nephrotic syndrome.
- Identifying predictors of poor response aids in tailoring treatment strategies and prognostication.