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Motilin in children with recurrent abdominal pain: a controlled study
1Department of Pediatrics, Herning Central Hospital, Denmark.
Insights
This study found no significant difference in serum motilin levels between children with and without recurrent abdominal pain. These findings do not support motilin as a cause of abdominal pain in children.
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Motility Disorders
Background:
- Recurrent abdominal pain is common in children.
- It is often presumed to be a gut motility disorder.
Purpose of the Study:
- To compare serum motilin levels in children with and without recurrent abdominal pain.
- To investigate the role of motilin in pediatric abdominal pain.
Main Methods:
- A controlled study involving 19 children with recurrent abdominal pain and 20 healthy controls (ages 6-15).
- Serum motilin levels were measured and compared between the two groups.
Main Results:
- No statistically significant difference in serum motilin levels was observed between children with and without abdominal pain.
- The median difference was 11 pmol/l (95% CI: -9 to +33).
Conclusions:
- The study did not find evidence to support motilin as a pathogenic factor in pediatric recurrent abdominal pain.
- Future research should examine motilin levels during pain episodes.
Abstract:
The aim of this study was to compare serum motilin levels in children with and without recurrent abdominal pain, based on the assumption that recurrent abdominal pain in children is a gut motility disorder. In this controlled study, 19 children between 6 and 15 years of age with recurrent non-organic abdominal pain and 20 control children between 6 and 15 years of age without abdominal pain or other functional somatic complaints were evaluated. No statistical significant difference was found in serum motilin levels between children with and without abdominal pain. Median difference between the groups was 11 pmol/l (95% confidence limits of median difference -9 to +33). This investigation could not support the assumption that motilin might be a pathogenic factor in children with recurrent abdominal pain. It is suggested, however, that future research should compare serum motilin levels during and between attacks of pain.