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Published on: February 23, 2017
Ceramic hydroxyapatite implants for the release of bisphosphonate
H Denissen1, E van Beek, C Löwik
1Department of Implantology, Academic Center for Dentistry Amsterdam (ACTA), Netherlands.
Bone and Mineral
|May 1, 1994
Summary
New ceramic implants releasing bisphosphonate can help maintain bone mass after tooth extraction. Rod-shaped hydroxyapatite implants show promising controlled release for preventing oral disease.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Drug Delivery Systems
Background:
- Maintaining bone mass post-tooth extraction is crucial for preventing oral diseases.
- Hydroxyapatite (HA) implants releasing bisphosphonate (P-C-P) offer a theoretical approach to enhance bone maintenance.
Purpose of the Study:
- To design and evaluate ceramic HA implants as controlled release systems for bisphosphonate (P-C-P).
- To assess the in vitro release characteristics of P-C-P from different HA implant configurations.
Main Methods:
- Four types of ceramic HA implants (rod/tube, varying porosity/density) were fabricated.
- Implants were loaded with P-C-P via adsorption or reservoir filling.
- In vitro release assays were conducted in saline at 37°C for 3 months.
Main Results:
- All tested HA implants demonstrated steady, controlled, and prolonged P-C-P release.
- Rod-shaped implants exhibited superior release properties compared to tube-shaped implants.
- Microporous HA rods (800°C) and macro/microporous HA rods (1300°C) showed significant potential.
Conclusions:
- Ceramic HA implants are effective in the sustained release of bisphosphonate.
- Optimized rod-shaped HA implants represent promising candidates for enhancing bone mass maintenance in oral applications.
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