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Single-plane multifrequency electrical impedance instrumentation

P M Record1

  • 1University of Keele, School of Post Graduate Medicine, Department of Biomedical Engineering and Medical Physics, Hospital Centre, Hartshill, Stoke, UK.

Physiological Measurement
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

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This study designed an impedance tomographic spectrometer for tissue analysis, achieving accurate measurements up to 3 MHz. This instrumentation advances the characterization of tissue impedance for distinguishing damaged tissue.

Area of Science:

  • Biomedical Engineering
  • Electrical Engineering
  • Medical Imaging

Background:

  • Tissue electrical properties, including resistivity and permittivity, change with electromagnetic radiation frequency.
  • Dielectric changes in tissue above 100 kHz offer potential for distinguishing damaged and necrotic tissue.
  • Tissue impedance in the medium frequency range (100 kHz-1 MHz) remains underexplored.

Purpose of the Study:

  • To design instrumentation for an impedance tomographic spectrometer.
  • To cover the frequency band of 10 kHz to 1 MHz for tissue impedance spectroscopy.
  • To achieve voltage measurement accuracy of at least 0.1% for sensitive resistivity imaging.

Main Methods:

  • Utilized commercially available operational amplifiers for instrumentation design.

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  • Employed PSPICE simulations to predict performance and accuracy.
  • Implemented and tested the designed instrumentation for amplitude and phase response.

    • Main Results:

    • Simulations indicated 0.1% accuracy up to 800 kHz, decreasing to 0.5% at 1 MHz.
    • Implemented design showed a flat amplitude (+/- 0.5 dB) and 50-degree phase shift from 10 kHz to 3 MHz.
    • Achieved a receive response of 0.13 dB to 5 MHz and a -40-degree phase shift at 3 MHz, with useful readings up to 3 MHz after channel correction.

    Conclusions:

    • The designed instrumentation provides accurate tissue impedance measurements within the 10 kHz to 3 MHz range.
    • This spectrometer is suitable for distinguishing damaged and necrotic tissue based on dielectric changes.
    • The developed system advances the characterization of tissue impedance at medium frequencies for potential clinical applications.