[Pharmacokinetics of intravenous Cefradin in normal and restricted renal function (author's transl)]

Half life and distribution volume of Cefradin were investigated in 22 patients with various degrees of renal function in which Cefradin was indicated and set in relation to glomerular filtration (determined by the 51Cr EDTA method). An average distribution volume of 21.8 +/- 3.5% of the body weight was found and a correlation between the half life of Cefradin and the glomerular filtration in the form of a power function. Estimations of levels were made from the pharmacokinetic data (half life, distribution volume) which serve as a basis for the recommendation of isoconcentration dosages. These are graduated according to the different degrees of renal insufficiency and given in tabular form for single injections and for continuous infusion drip therapy.