Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic bronchitis: reflex on the pulmonary circulation

A Pezza1, F De Blasio

  • 1Chair of Pneumology, University of Naples Federico II Medical School, Italy.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Raw BIA variables are predictors of muscle strength in patients with chronic obstructive pulmonary disease.

European journal of clinical nutrition·2017
Same author

Efficacy of standard rehabilitation in COPD outpatients with comorbidities.

The European respiratory journal·2010
Same author

Role of hyperinflation vs. deflation on dyspnoea in severely to extremely obese subjects.

Acta physiologica (Oxford, England)·2008
Same author

[Abdominal actinomycosis and retroperitoneal fibrosis. Considerations on a clinical case].

Chirurgia italiana·2002
Same author

An observational study on the epidemiology of respiratory tract bacterial pathogens and their susceptibility to four injectable beta-lactam antibiotics: piperacillin, piperacillin/tazobactam, ceftazidime and ceftriaxone.

Journal of chemotherapy (Florence, Italy)·2001
Same author

A Doubting Thomas dealing with pulmonary rehabilitation.

Chest·2000
Same journal

Preventable yet persistent: silicosis and gaps in public health policy - a narrative review.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2026
Same journal

Takotsubo syndrome due to occupational stress in a physician.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2026
Same journal

Spirometry after treatment completion for pulmonary tuberculosis - a necessity?

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2026
Same journal

Heart failure at the crossroads of climate change and environmental health: emerging risks, mechanistic insights, and future directions.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2026
Same journal

Aspiration pneumonia in stroke survivors: prevalence and clinical associations at Bolan Medical Complex.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2026
Same journal

The silent fractures: unmasking osteoporosis in south Indian chronic obstructive pulmonary disease patients.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2026
See all related articles

Hypoxia in chronic obstructive pulmonary disease (COPD) causes pulmonary vasoconstriction and increases pulmonary artery pressure (PAP), impacting survival. Understanding the endothelium

Area of Science:

  • Pulmonary Medicine
  • Vascular Physiology

Background:

  • Chronic obstructive pulmonary disease (COPD) is associated with low alveolar oxygen and hypoxia.
  • Hypoxia triggers pulmonary vasoconstriction, leading to increased pulmonary artery pressure (PAP).
  • Elevated PAP in COPD patients correlates with poorer survival rates.

Purpose of the Study:

  • To investigate the mechanisms of hypoxia-induced pulmonary vasoconstriction in COPD.
  • To identify vasoactive substances produced by the endothelium that influence pulmonary vascular tone.
  • To understand the role of cyclooxygenase and lipoxygenase pathways in COPD-related pulmonary hypertension.

Main Methods:

  • Review of existing literature on pulmonary vascular regulation in COPD.
  • Analysis of the role of endothelial-derived substances (e.g., endothelin, EDRF).

Related Experiment Videos

  • Exploration of cyclooxygenase and lipoxygenase pathway involvement.

    • Main Results:

    • Hypoxia-induced pulmonary vasoconstriction and PAP increase are key features of COPD.
    • Endothelial dysfunction and the production of vasoactive mediators contribute to pulmonary hypertension.
    • Metabolites from cyclooxygenase and lipoxygenase pathways are implicated.

    Conclusions:

    • Further identification of endothelial substances is crucial for understanding pulmonary vascular control in COPD.
    • Targeting these pathways may lead to novel therapeutic strategies for COPD-related pulmonary hypertension.
    • Improved understanding could enhance disease management and patient prognosis.