Related Experiment Videos
Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia
J Bernhagen1, T Calandra, A Cerami
1Picower Institute for Medical Research, Manhasset, NY 11030.
Trends in Microbiology
|June 1, 1994
Abstract:
The cytokine macrophage migration inhibitory factor (MIF) is a major protein constituent of the anterior pituitary gland released into the bloodstream during endotoxaemia. For many years, MIF had been thought to be a T cell product associated with delayed-type hypersensitivity reactions. The identification of MIF as a pituitary 'stress' hormone provides an important link in the regulation of systemic inflammatory responses by the central nervous system.