Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cortical specification: microcircuits, perceptual identity, and an overall perspective

M Sur1

  • 1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.

Perspectives on Developmental Neurobiology
|January 1, 1993
PubMed
Summary

Early visual input reshapes the developing auditory cortex, altering its microcircuitry and perceptual identity. This demonstrates how environmental signals instruct cortical development during critical periods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prefrontal Cortex subregions provide distinct visual and behavioral feedback modulation to the Primary Visual Cortex.

bioRxiv : the preprint server for biology·2024
Same author

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling.

Molecular psychiatry·2017
Same author

Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro.

Translational psychiatry·2016
Same author

UNDIFFERENTIATED ENDOMETRIAL CANCER, A DIFFERENT ENTITY WITH AN AGGRESSIVE BEHAVIOR: IGCS-0060 Uterine Cancer, including Sarcoma.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2015
Same author

Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder.

Molecular psychiatry·2015
Same author

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.

Molecular psychiatry·2015

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Sensory Processing

Background:

  • Cortical areas develop their microcircuitry and perceptual identity late in development.
  • The influence of early sensory input on cortical specification remains an area of active research.

Purpose of the Study:

  • To investigate if and how developmental input activity patterns influence cortical features.
  • To determine the instructive role of visual input in the developing auditory cortex.

Main Methods:

  • Redirecting visual projections to the auditory pathway in developing ferrets.
  • Analyzing the resulting changes in auditory cortex microcircuitry and perceptual responses.

Main Results:

  • The developing auditory cortex, when receiving visual input, exhibited altered microcircuitry.

Related Experiment Videos

  • The perceptual identity of the primary auditory cortex was respecified to respond to visual stimuli.
  • Certain features of the primary auditory cortex remained unchanged despite the altered input modality.

    • Conclusions:

    • Input activity patterns are crucial environmental cues that interact with intrinsic developmental programs for cortical specification.
    • Appropriate environmental signals must be present at specific developmental times to influence cortical specification.