Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional specification during cerebellar development

M Wassef1, L Bally-Cuif, R M Alvarado-Mallart

  • 1INSERM U106, Hôpital de la Salpêtrière, Paris, France.

Perspectives on Developmental Neurobiology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatic mutational landscape of extracranial arteriovenous malformations and phenotypic correlations.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Versatile and precise gene-targeting strategies for functional studies in mammalian cell lines.

Methods (San Diego, Calif.)·2017
Same author

The Multiple Facets of PRC2 Alterations in Cancers.

Journal of molecular biology·2016
Same author

Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors.

Cell cycle (Georgetown, Tex.)·2016
Same author

Ossifying fibromas of the paranasal sinuses: diagnosis and management.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2016
Same author

Aspergillus spp. invasive external otitis: favourable outcome with a medical approach.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same journal

Functional coupling of neurotransmitters with second messengers during cleavage divisions: facts and hypotheses.

Perspectives on developmental neurobiology·1999
Same journal

Neurotransmitters and neurodevelopment. Role of dopamine in neurite outgrowth, target selection and specific synapse formation.

Perspectives on developmental neurobiology·1999
Same journal

Diversity of the endogenous opioid system in development. Novel signal transduction translates multiple extracellular signals into neural cell growth and differentiation.

Perspectives on developmental neurobiology·1999
Same journal

Somatostatin as a neurotrophic factor. Which receptor/second messenger transduction system is involved?

Perspectives on developmental neurobiology·1999
Same journal

Cholinergic regulation of cortical development and plasticity. New twists to an old story.

Perspectives on developmental neurobiology·1999
Same journal

Neurotransmitters and neurotrophins collaborate to influence brain development.

Perspectives on developmental neurobiology·1999
See all related articles

Early chick and quail embryo development shows Wnt-1 and engrailed gene expression in the cerebellum. Heterotopic transplantation reveals neural tube signals influence embryonic brain development and cell fate.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Genetics

Background:

  • The rostral cerebellum anlage expresses Wnt-1 and engrailed genes at early developmental stages (HH12) in chick and quail embryos.
  • Wnt-1 encodes a secreted molecule, and engrailed encodes a homeodomain protein, both crucial in early neural development.

Purpose of the Study:

  • To analyze the developmental potential of different cerebellar anlage regions.
  • To investigate the influence of neural tube signals on embryonic brain development and cell fate determination.

Main Methods:

  • Heterotopic transplantation of quail and mouse embryonic neural tubes into HH12 chick embryos' prosencephalon.
  • Analysis of gene expression patterns and developmental fate changes in transplanted tissues.

Related Experiment Videos

Main Results:

  • Neural tube signals continue to operate in avian and murine embryos, influencing developmental trajectories.
  • Metencephalic, mesencephalic, and prosencephalic territories of HH12 chick embryos remain competent to alter cell fate in response to these signals.
  • The Wnt-1 expression domain (caudal mesencephalic vesicle) exhibits significant organizing properties throughout avian and rodent development.

Conclusions:

  • Early embryonic neural tube signals play a critical role in organizing brain development and regionalization.
  • Wnt-1 and engrailed genes are implicated in these inductive interactions, potentially mediating cell fate changes.
  • Further research is needed to elucidate the precise role of Wnt-1 in cerebellar development and regionalization.