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[Modification of the radiosensitivity of cultured "Vero" cells by cumene hydroperoxide]
N Drancourt1, S Waultier, R Paulin
1Centre de formation et de Recherche sur les Isotopes, les Rayonnements et leurs Applications à la Médecine, l'Industrie et la Radioécologie (I.R.A.M.I.R.), Faculté de Médecine, Marseille, France.
Abstract:
Cumene-hydroperoxide is a radical reaction promoter. Vero cells monolayers treated with this compound were irradiated with gamma-rays and their radiosensitization was compared with that of irradiated, non-treated control cells. Cumene-hydroperoxide treated cells showed a paradoxal radioresistance. We propose a possible buffer-like effect of cumene-hydroperoxide to explain these results.