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Related Experiment Videos

New international reference preparation for proteins in human serum (RPPHS)

J T Whicher1, R F Ritchie, A M Johnson

  • 1Institute for Cancer Studies, St. James's University Hospital, Leeds, UK.

Clinical Chemistry
|June 1, 1994
PubMed
Summary
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Poor agreement in plasma protein measurements between laboratories worldwide led to the development of a new, optically clear secondary reference material. This initiative aims to improve global standardization and accuracy in clinical diagnostics.

Area of Science:

  • Clinical Chemistry
  • Biotechnology
  • Laboratory Medicine

Background:

  • Quality-control surveys reveal significant discrepancies in plasma protein measurements across global laboratories.
  • Existing international reference materials and manufacturer standards exhibit inconsistent values, hindering accurate diagnostics.
  • Challenges include limited availability, unclear usage guidelines, and turbidity of primary materials in modern immunoassays.

Purpose of the Study:

  • To address the critical need for standardized plasma protein measurements.
  • To introduce a widely available, optically clear secondary reference material for global use.
  • To foster collaboration among manufacturers, clinical laboratories, professional societies, and regulators.

Main Methods:

  • Development and distribution of a novel, optically clear secondary reference material for plasma proteins.

Related Experiment Videos

  • Collaboration with diverse stakeholders including diagnostic manufacturers, clinical laboratories, and regulatory bodies.
  • Establishing a unified approach to reference material utilization in quality control.

    • Main Results:

    • Successful production of a stable, optically clear secondary reference material for plasma proteins.
    • Facilitation of improved between-laboratory agreement in plasma protein quantification.
    • Establishment of a framework for global adoption and consistent application of the new reference material.

    Conclusions:

    • The developed secondary reference material offers a viable solution to the long-standing issue of plasma protein measurement variability.
    • Enhanced standardization through this material is expected to improve the reliability of clinical laboratory results worldwide.
    • The collaborative effort demonstrates a successful model for addressing complex challenges in laboratory medicine.