Gadolinium chelate MR contrast agents
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Updated: Nov 10, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Abstract:
Several Gadolinium chelates are now available or will shortly become available. They differ in being, variously, ionic or non-ionic and in being of higher or lower osmolality. Although they differ in detail of chemical structure, they are all based on the same general principle and all possess the same extracellular distribution pharmacokinetics (Gd BOPTA excepted), typical for their molecular size. In terms of efficacy there is no convincing evidence that any one is clinically superior to the others. As regards reducing osmolality, it is not self evident that, in the recommended and currently widely used dosage regimens, high osmolality presents any real clinical problems. However, if 'high dosage' regimens or dynamic bolus imaging come to be more widely used, then the newer agents may be perceived to have clinical advantages.
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