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Related Experiment Videos

Embryonic heart rate in dated human embryos

J Wisser1, P Dirschedl

  • 1Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.

Early Human Development
|May 1, 1994
PubMed
Summary
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Embryonic heart rate (EHR) in early human development increases with growth, peaking around 63 days. A subsequent decline in EHR may indicate potential pregnancy complications, highlighting its role in early embryonic assessment.

Area of Science:

  • Embryology
  • Reproductive Medicine
  • Fetal Cardiology

Background:

  • Early embryonic development is crucial for successful pregnancy.
  • Embryonic heart rate (EHR) is a key indicator of fetal well-being.
  • Transvaginal ultrasonography is a standard method for early pregnancy assessment.

Purpose of the Study:

  • To prospectively measure embryonic heart rate (EHR) in human embryos during the first trimester.
  • To correlate EHR with embryonic growth and developmental stage.
  • To investigate the predictive value of low EHR for pregnancy outcomes.

Main Methods:

  • Simultaneous B-mode and time-motion transvaginal ultrasonography were used.
  • Measurements were taken in 139 singleton and 46 embryos from multiple pregnancies (37-98 postmenstrual days).

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  • A total of 348 EHR measurements were recorded in relation to embryonic length.

    • Main Results:

    • Embryonic heart rate (EHR) increased up to 63 postmenstrual days or 22 mm greatest length.
    • A steady decrease in EHR was observed after this peak.
    • 27 embryos with low EHR relative to length all resulted in missed abortions.

    Conclusions:

    • The increase in EHR parallels embryonic heart morphological development.
    • The decline in EHR post-peak is interpreted as a functional adaptation to cardiac muscle development.
    • Low EHR may be an early predictor of embryonic demise.