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Sensitivity of AMPA receptors to pentobarbital
F A Taverna1, B R Cameron, D L Hampson
1Department of Physiology, Faculty of Medicine, University of Toronto, Ont., Canada.
European Journal of Pharmacology
|May 17, 1994
Abstract:
The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital with the receptor was reduced. This evidence demonstrates that the GluR2 subunit alters the structure of AMPA receptors in such a way as to facilitate any interaction with this barbiturate.