[Choriocarcinoma in extrauterine tubal pregnancy]

Hydatidiform moles and chorionic carcinomas associated with ectopic pregnancy are extremely rare. We report on three cases of non-metastatic GTD after tubar pregnancy of low and medium risk in the WHO prognostic score and FIGO-stage II in each case. Two of them required several courses of (poly-) chemotherapy to reach complete remission (CR). The follow-up was on average 36.6 months, without any metastases and recurrences. One woman was delivered of a healthy infant. All cases were surgically treated with extirpation of the affected adnexa. Additionally, in one case hysterectomy was necessary to reach CR. As reported in the literature, chorionic carcinomas associated with ectopic pregnancy are often very aggressive and show a metastasis rate of 75% at time of diagnosis. For this reason it is essential, to examine tubar pregnancy by histopathology carefully to define small and in situ changes. The cases presented stress the need for appropriate HCG and clinical monitoring.