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[Cell therapy and its risks]

J R Bohl1, H H Goebel, L Pötsch

  • 1Abteilung für Neuropathologie, Universität Mainz.

Fortschritte Der Medizin
|June 30, 1994
PubMed
Summary
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Cellular therapy, involving parenteral administration of fresh, frozen, or lyophilized cells, carries significant risks. Complications, often allergic or hyperergic, necessitate careful risk-benefit assessment, prioritizing patient safety.

Area of Science:

  • Immunology
  • Pharmacology
  • Alternative Medicine

Context:

  • Cellular therapy, encompassing fresh, frozen, or lyophilized cell administration, is a recognized medical practice.
  • Despite a ban on dried preparations in Germany since 1987, fresh cell injections remain permissible.
  • This therapy involves administering heterologous biological material, posing inherent risks.

Purpose:

  • To review the safety and potential complications associated with cellular therapy.
  • To highlight the risks of parenteral cell administration, particularly fresh cell injections.
  • To emphasize the need for a thorough risk-benefit analysis in alternative medical treatments.

Summary:

  • Parenteral administration of various cell types constitutes cellular therapy.

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  • Complications, frequently allergic/hyperergic reactions akin to EAE and EAN, have been reported.
  • Risks associated with injection therapy and the specific dangers of cell therapy must be considered.

    • Impact:

    • Informed decision-making for patients considering cellular therapy.
    • Enhanced awareness among healthcare providers regarding potential adverse events.
    • Reinforcement of the 'nil nocere' principle in medical practice, especially in alternative treatments.