Aspergillosis of the orbit with immunosuppressive therapy

A case report of aspergillosis of the orbit in a 27-year-old renal transplant patient receiving immunosuppressive therapy is presented. The predominant clinical features were slowly progressive, painful exophthalmos and fever of undetermined origin. Orbital biopsy established the diagnosis. The histopathologic characteristics of the infectious process changed from the time of biopsy to the time of autopsy, reflecting the patient's changing immunologic status.