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Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping
B Crouau-Roy1, C Amadou, C Bouissou
1CRPG CNRS, UPR 8291, CHU Purpan, Toulouse, France.
Genomics
|May 1, 1994
Abstract:
OTF3 (octamer transcription factor 3) is a transcription factor containing a POU-specific domain and a homeodomain that could play a role in early development. In situ hybridization and pairwise linkage analysis showed that OTF3 gene maps close to the human MHC (major histocompatibility complex). In this paper, we define its localization within the MHC, around 100 kb telomeric to HLA-C, using a combination of physical and genetic analyses.