Optimised averaging by on-line statistical verification of response in clinical electrodiagnostic trials

Real time statistical verification of the averaged response in many established electrodiagnostic tests may result in a substantially reduced number of presented stimuli thus minimising the test's duration and reducing the overall time load on the patient examined. Furthermore, a sufficient number of stimuli may be automatically established in an objective statistical way by accounting for the response amplitude and variance, noise amplitude etc., resulting in averages with matching signal to noise ratio. A technique of real time statistical verification of the response based upon single trial data analysis was developed and verified in clinical electroretinographic (ERG) tests.