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Prediction of bone adaptation using damage accumulation

P J Prendergast1, D Taylor

  • 1Mechanical Engineering Department, Trinity College, Dublin, Ireland.

Journal of Biomechanics
|August 1, 1994
PubMed
Summary
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Bone adaptation follows mathematical laws, with a new damage-adaptive remodelling law predicting stress history and bone microstructure changes. This model shows over/undershoot in bone adaptation, differing from strain-adaptive models.

Area of Science:

  • Biomechanics
  • Bone Biology
  • Computational Biology

Background:

  • Bone adaptation to mechanical load is a long-observed phenomenon.
  • Current strain-adaptive remodelling laws require numerous empirical constants, limiting predictive power.
  • An alternative hypothesis suggests bone adapts by regulating microstructural damage.

Purpose of the Study:

  • To derive a mathematical law for bone adaptation based on damage regulation.
  • To investigate if damage-adaptive remodelling can predict the time course of bone adaptation.
  • To compare predictions with existing strain-adaptive remodelling models.

Main Methods:

  • Proposed hypotheses for developing damage-adaptive remodelling laws.
  • Derived an integral remodelling law incorporating stress history.

Related Experiment Videos

  • Simulated adaptive response of a bone diaphysis to altered torsional load.

    • Main Results:

    • The derived damage-adaptive remodelling law naturally accounts for tissue stress history.
    • Simulations showed physically reasonable predictions for bone adaptation.
    • Early remodelling predictions align with strain-adaptive models, but later stages diverge.

    Conclusions:

    • Damage-adaptive remodelling offers a new framework for predicting bone adaptation.
    • The model predicts stress history-dependent adaptation, including undershoot/overshoot phenomena.
    • This approach may improve simulations of bone adaptation around orthopaedic implants.