[Bilateral bronchioloalveolar carcinoma, showing familial aggregation of lung cancer]

Bilateral bronchioloalveolar carcinoma in a 56-year-old female is reported. In June 1992, an abnormal shadow was noted on chest X-ray during mass screening. Sputum cytology revealed class V, adenocarcinoma. Mass shadow in both lower lobes were found on chest computed tomography. Simultaneous bilateral thoracotomy was performed by submammary transverse skin incision at the level of the fourth intercostal space. Right lower lobectomy and left S9 partial resection were performed. Bronchioloalveolar carcinoma was confirmed by microscopic findings in both specimens. Four of seven siblings had lung cancer and one had simultaneous renal cell carcinoma. Furthermore, the patient's father, two maternal uncles, one cousin and one nephew also had lung cancer. Two of the brothers and the nephew with lung cancer were confirmed to have well differentiated adenocarcinoma by pathological examination.