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Related Experiment Videos

Graves' disease complicating pregnancy

W Phuapradit1, N Saropala, R Rajatanavin

  • 1Department of Obstetrics & Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|July 1, 1993
PubMed
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Graves' disease in pregnancy, affecting 0.1% of deliveries, was managed with propylthiouracil. While maternal and perinatal outcomes varied with thyroid status, fetal hypothyroidism occurred in 12.2%, necessitating careful drug monitoring and infant follow-up.

Area of Science:

  • Endocrinology
  • Obstetrics
  • Neonatology

Background:

  • Graves' disease is an autoimmune disorder causing hyperthyroidism.
  • Thyroid dysfunction during pregnancy poses risks to both mother and fetus.
  • Accurate diagnosis and management are crucial for favorable outcomes.

Purpose of the Study:

  • To analyze the prevalence, management, and outcomes of Graves' disease in pregnant patients.
  • To investigate the relationship between maternal thyroid status and maternal/perinatal complications.
  • To assess the incidence of fetal hypothyroidism and the need for neonatal monitoring.

Main Methods:

  • Retrospective analysis of 114 pregnancies complicated by Graves' disease from 1981-1992.
  • Review of maternal and perinatal outcomes, including thyroid status at delivery.

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  • Evaluation of fetal and neonatal outcomes, specifically thyroid function.

    • Main Results:

    • Graves' disease complicated 0.1% of over 85,000 deliveries.
    • Propylthiouracil was the primary medical treatment.
    • Maternal outcomes were linked to thyroid status; 12.2% of neonates developed hypothyroidism.

    Conclusions:

    • Graves' disease in pregnancy requires careful management with antithyroid drugs.
    • Maternal thyroid status at delivery significantly impacts maternal and perinatal outcomes.
    • Close monitoring of antithyroid drug dosage and neonatal-infant follow-up are essential to prevent fetal hypothyroidism.