Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Secular trends in cerebrovascular mortality

H Kesteloot1, S Sasaki, J Xie

  • 1Department of Epidemiology, School of Public Health, K.U. Leuven, Belgium.

Journal of Human Hypertension
|June 1, 1994
PubMed
Summary

Cerebrovascular mortality significantly decreased in Western countries since 1950, with trends predating widespread hypertension treatment. Declines are linked to reduced salt and saturated fat intake, not solely pharmacological interventions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iatrogenic Atrail Septal Defect After Mitral Valve Replacement.

Acta clinica Belgica·2016
Same author

Nutrition and health.

Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie·2010
Same author

A new method of counting reticulocytes using fluorescence microscopy.

La Presse medicale·2010
Same author

Methyldopa in the Treatment of Hypertension.

British medical journal·2010
Same author

Effect of 35 years beta-adrenergic blockade therapy on autonomic cardiovascular modulation. A case study.

Acta clinica Belgica·2010
Same author

Age at death from different diseases: the flemish experience during the period 2000-2004.

Acta clinica Belgica·2008

Area of Science:

  • Epidemiology
  • Public Health
  • Cardiovascular Disease Research

Background:

  • Western countries observed a significant decline in cerebrovascular mortality starting in 1950.
  • Mass population-level treatment for hypertension began in the early 1970s.
  • A notable decrease in cerebrovascular mortality was evident even before widespread hypertension treatment initiatives.

Purpose of the Study:

  • To investigate the influence of pharmacological hypertension treatments on the observed decline in cerebrovascular mortality between 1950 and 1987.
  • To analyze linear time-trends in cerebrovascular mortality during the specified period.

Main Methods:

  • Calculation of linear time-trends for cerebrovascular mortality from 1950 to 1987.
  • Statistical analysis of mortality data, including correlation coefficients.

Related Experiment Videos

  • Review of epidemiological data concerning nutritional factors.

    • Main Results:

    • Highly significant linear time-trends (correlation coefficients > 0.98) were observed for the entire period.
    • The decrease in cerebrovascular mortality is strongly correlated with reduced population intake of salt and saturated fats.
    • Eastern European countries showed increased cerebrovascular mortality, paralleling increased all-cause and ischemic heart disease mortality, linked to high saturated fat intake.

    Conclusions:

    • The decline in cerebrovascular mortality is primarily attributed to dietary changes, specifically decreased salt and saturated fat consumption.
    • Pharmacological treatment of hypertension likely played a less significant role in the early downward trend compared to nutritional factors.
    • Nutritional epidemiology is crucial for understanding long-term trends in cerebrovascular mortality, even in older age groups.