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The ancient regulatory-protein family of WD-repeat proteins
E J Neer1, C J Schmidt, R Nambudripad
1Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Nature
|September 22, 1994
Abstract:
WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.