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[Trazodone versus flunitrazepam in premedication in day-care surgery]
M Bonazzi1, A Riva, M Marsicano
1Servizio di Anestesia-Rianimazione e Terapia Intensiva, Ospedale Bassini, Cinisello Balsamo (Milano), Regione Lombardia, USSL 66.
Minerva Anestesiologica
|March 1, 1994
Summary
Trazodone offers a faster recovery of psychomotor function compared to flunitrazepam for surgical premedication. This makes trazodone a viable alternative to benzodiazepines in outpatient surgical settings.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Premedication is crucial for managing patient anxiety and optimizing surgical outcomes.
- Benzodiazepines are commonly used for premedication, but alternatives are sought to minimize side effects.
Purpose of the Study:
- To compare the efficacy and safety of flunitrazepam versus trazodone as premedication for day-case surgery.
- To assess preoperative sedation, intraoperative analgesia, and postoperative recovery, including psychomotor performance.
Main Methods:
- A prospective, single-blind study involving 86 patients undergoing termination of pregnancy.
- Patients received either oral flunitrazepam 2 mg or trazodone 50 mg 45 minutes pre-surgery.
- Anesthesia included intravenous fentanyl and ketamine; psychomotor performance was evaluated using specific tests.
Main Results:
- Flunitrazepam induced deeper preoperative sedation.
- No significant differences were observed in intraoperative analgesia or immediate arousal time.
- Trazodone demonstrated a more rapid recovery of psychomotor performance post-surgery.
Conclusions:
- Trazodone provides a faster psychomotor recovery compared to flunitrazepam after day-case surgery.
- Trazodone represents a potentially effective alternative to benzodiazepines for premedication in outpatient surgical procedures.