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Pathways in thymus- and bone marrow-derived lymphatic leukemia in mice
Bibliotheca Haematologica
|January 1, 1975
Summary
Radiation and radiation leukemia virus induce thymus-derived (T) lymphocyte leukemias in mice. Chemical carcinogens also cause leukemias, mostly bone marrow-derived (B) lymphocyte origin, but some T-cell or unclassified types.
Area of Science:
- Immunology
- Oncology
- Virology
Background:
- Leukemias can arise from different lymphocyte populations.
- Radiation and chemical carcinogens are known to induce cancer.
Purpose of the Study:
- To investigate the cellular origin of radiation- and chemical carcinogen-induced leukemias in mice.
- To understand the role of specific lymphoid subpopulations in leukemia development.
Main Methods:
- Induction of leukemia in C57BL/6 and SJL/J mice using radiation and chemical carcinogens.
- Analysis of lymphoid cell origin (T lymphocyte, B lymphocyte, or other) in induced leukemias.
Main Results:
- Radiation-induced leukemias in C57BL/6 mice were of thymus-derived (T) lymphocyte origin.
- Chemical carcinogen-induced leukemias in SJL/J mice were predominantly of bone marrow-derived (B) lymphocyte origin, with some T-cell or unclassified types.
- A leukemogenic agent was detected in bone marrow post-radiation, while preleukemic/leukemic cells were found post-chemical carcinogen treatment.
Conclusions:
- Leukemia induction involves specific interactions between agents and distinct lymphoid cell types.
- Both T and B lymphocytes are susceptible to malignant transformation, leading to different leukemia subtypes.
- Further research may clarify the role of stem cells in unclassified leukemias.