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[Bias of index of T-lymphocytes and chronic inflammatory dermatoses]
H Michalaki1, J F Nicolas, H Bour
1Laboratoire Greca, Institut Gustave-Roussy, Villejuif, France.
Pathologie-Biologie
|March 1, 1994
Abstract:
The pathogenesis of chronic inflammatory and autoimmune diseases is still not understood. The hypothesis that a bias in the T cell receptor repertoire could explain the susceptibility of some individuals to a particular disease was recently proposed on the basis of results obtained in animal models of human diseases. In this review, we focus on the structure of the T cell receptor and on the new insights in the study of the T cell repertoire in human inflammatory diseases, with special emphasis to skin disorders.