Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interleukin-4: from B-lymphocyte to fibroblast]

V Salmon-Ehr1, P Gillery, B Kalis

  • 1Laboratoire de Recherche Biomédicale en Dermatologie, CNRS ERS 0017, Faculté de Médicine, Reims, France.

Pathologie-Biologie
|March 1, 1994
PubMed
Summary

Interleukin-4 (IL-4) is a cytokine with diverse effects beyond B-cells, notably activating fibroblasts to produce extracellular matrix. This review explores IL-4

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing.

Experimental gerontology·2019
Same author

Extracellular matrix and wound healing.

Pathologie-biologie·2014
Same author

Analytical methods for measuring collagen XIX in human cell cultures, tissue extracts, and biological fluids.

Analytical biochemistry·2013
Same author

Celebration of the 50th anniversary of the foundation of the French society for connective tissue research. Its short history in the frame of the origin and development of this discipline.

Pathologie-biologie·2012
Same author

17Beta-oestradiol up-regulates the expression of a functional UDP-glucose dehydrogenase in articular chondrocytes: comparison with effects of cytokines and growth factors.

Rheumatology (Oxford, England)·2008
Same author

[Role of matrikins in melanoma progression].

Annales pharmaceutiques francaises·2006

Area of Science:

  • Immunology and Cell Biology
  • Cytokine Signaling
  • Extracellular Matrix Regulation

Context:

  • Interleukin-4 (IL-4), initially identified for its role in B-lymphocyte proliferation and immunoglobulin secretion.
  • IL-4 exhibits broader, pleiotropic effects on various cell types.
  • Fibroblasts are key cells involved in extracellular matrix production, crucial for tissue structure and repair.

Purpose:

  • To review the multifaceted roles of Interleukin-4 (IL-4).
  • To emphasize IL-4's regulatory functions on connective tissue cell activities.
  • To discuss IL-4's potential involvement in pathological conditions like fibrosis, wound healing, and tumor invasion.

Summary:

  • Interleukin-4 (IL-4) stimulates B-lymphocytes and IgG1 secretion, formerly known as B-Cell Growth Factor-1 (BCGF-1) or B-Cell Stimulatory Factor-1 (BSF-1).

Related Experiment Videos

  • Beyond its immunological functions, IL-4 activates fibroblasts, promoting the synthesis of extracellular matrix components.
  • This review consolidates current data on IL-4's impact on connective tissue cells and its implications in diseases.

    • Impact:

    • Provides a comprehensive overview of IL-4's non-immune functions.
    • Highlights IL-4's significance in understanding connective tissue remodeling.
    • Suggests potential therapeutic targets related to IL-4 in fibrotic diseases, wound healing, and cancer progression.