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Effects of the CCK receptor antagonist MK-329 on food intake in broiler chickens

M Covasa1, J M Forbes

  • 1Department of Animal Physiology and Nutrition, University of Leeds, UK.

Pharmacology, Biochemistry, and Behavior
|June 1, 1994
PubMed

Insights

The cholecystokinin (CCK) receptor antagonist MK-329 did not affect food intake or conditioning in broiler chickens at lower doses. Higher doses of MK-329 increased food intake, questioning CCK

Area of Science:

  • Animal Science
  • Neuroscience
  • Pharmacology

Background:

  • Cholecystokinin (CCK) is a peptide hormone involved in regulating satiety and feeding behavior.
  • The role of endogenous CCK in avian feeding behavior, particularly in chickens, remains incompletely understood.

Purpose of the Study:

  • To investigate the effects of the CCK receptor antagonist MK-329 on food intake and learned feeding responses in broiler chickens.
  • To explore the involvement of endogenous CCK in satiety and appetite regulation in chickens.

Main Methods:

  • Broiler chickens were administered varying doses of MK-329 via intraperitoneal and intravenous injections.
  • Conditioning effects were assessed using a colored food paradigm to evaluate learned preferences or aversions.
  • Food intake was measured following drug administration.
  • The ability of MK-329 to block CCK-induced feeding reduction was also tested.

Main Results:

  • Lower doses (8.0–32.0 µg/kg) of MK-329 did not alter food intake or condition color preferences/aversions.
  • Higher doses (90–360 µg/kg) of MK-329 administered intraperitoneally significantly increased food intake.
  • Intravenous administration of MK-329 also dose-dependently increased food intake, with the maximal effect at 70 µg/kg.
  • CCK-induced feeding reduction was not antagonized by MK-329 pretreatment.

Conclusions:

  • Endogenous CCK may not play a significant role in regulating satiety in broiler chickens.
  • MK-329 exhibits dose-dependent effects on food intake in chickens, suggesting a complex interaction with appetite regulation.
  • Further research is needed to elucidate the precise mechanisms of CCK signaling in avian feeding behavior.

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