Respiratory muscle blood flow in the fetal lamb during apnoea and breathing

We measured blood flow to the respiratory muscles of the fetal lamb using the radioactively-labelled microsphere technique in order to assess whether fetal breathing is an energetically costly activity as has been reported. Diaphragm flow ranged from 6.4-35.2 ml.min-1.100 g-1 during fetal apnoea and rose to 21.1-615 ml.min-1.100 g-1 during fetal breathing (P < 0.02; n = 7). Parasternal muscle flow also increased significantly (P < 0.02) between fetal apnoea and breathing while external and internal intercostal flows did not change. Expressed as a percentage of cardiac output the diaphragm received 0.08-0.28% during apnoea and 0.22-2.2% during fetal breathing. Neither placental blood flow nor fetal O2 consumption increased significantly between fetal apnoea and breathing. We conclude that the levels of perfusion required by the respiratory muscles for breathing in the fetus are inconsistent with fetal breathing costing a large proportion of the fetal O2 budget.