The neuromuscular junction. Muscle fibre type differences, plasticity and adaptability to increased and decreased...

The neuromuscular junction (NMJ) of adult mammalian muscle is the site of the transduction of electrical stimuli, generated by the nervous system, to the underlying muscle fibres, resulting in muscle action. It has been demonstrated that, in some ways, the morphology of the NMJ is specific to muscle fibre type. It is also known that while the structure of the NMJ generally remains stable in young, healthy adults, a subtle form of remodelling continuously occurs at this synapse. The morphology and physiology of the NMJ have been shown to adapt to both increased, and decreased use. Indeed, morphological changes of the NMJ are associated with functional alterations in neuromuscular transmission. Increased activity of the myoneural synapse results in adaptations that enhance neuromuscular transmission and, thus, muscle performance. Similarly to increased usage, decreased neuromuscular activity results in structural alterations of the NMJ. However, unlike those responses observed with enhanced activity, decreased recruitment of the myoneural synapse can impair neuromuscular transmission and muscle performance. Thus, the NMJ demonstrates both anatomical and physiological adaptations following substantial changes in its pattern of activity. These NMJ adaptations can affect the functional capacity of skeletal muscle in vivo.