Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary ovarian carcinoma

H H Gallion1, S A Smith

  • 1Division of Gynecologic Oncology, University of Kentucky Medical Center, Lexington.

Seminars in Surgical Oncology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BRCA1 expression in a large series of sporadic ovarian carcinomas: a Gynecologic Oncology Group study.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2006
Same author

Insulin sensitisation in the treatment of Type 2 diabetes.

Expert opinion on investigational drugs·2003
Same author

Vaccinia virus complement control protein ameliorates hyperacute xenorejection by inhibiting xenoantibody binding.

Transplantation proceedings·2002
Same author

Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism.

Biochemical Society transactions·2002
Same author

New insights into differential baroreflex control of heart rate in humans.

American journal of physiology. Heart and circulatory physiology·2002
Same author

Vaccinia virus complement control protein inhibits hyperacute xenorejection.

Transplantation proceedings·2002
Same journal

Preoperative chemoradiation for locally advanced rectal cancer: rationale, technique, and results of treatment.

Seminars in surgical oncology·2003
Same journal

Preoperative chemoradiation for locally advanced rectal adenocarcinoma-the University of Florida experience.

Seminars in surgical oncology·2003
Same journal

Postoperative adjuvant therapy for pancreatic cancer.

Seminars in surgical oncology·2003
Same journal

Conformal chemoradiation for primary and metastatic liver malignancies.

Seminars in surgical oncology·2003
Same journal

Gastrectomy, peritonectomy, and perioperative intraperitoneal chemotherapy: the evolution of treatment strategies for advanced gastric cancer.

Seminars in surgical oncology·2003
Same journal

Combined modality therapy in esophageal cancer: the Memorial experience.

Seminars in surgical oncology·2003
See all related articles

Genetic predisposition is a significant risk factor for ovarian cancer. Women with a family history should receive genetic counseling and surveillance for early detection.

Area of Science:

  • Gynecologic Oncology
  • Cancer Genetics
  • Hereditary Cancer Syndromes

Background:

  • Ovarian cancer is the leading cause of death from gynecologic cancer in the U.S.
  • While etiology is unknown, risk factors include age, nulliparity, environmental factors, and genetic predisposition.
  • Hereditary syndromes like breast-ovarian cancer syndrome significantly increase ovarian cancer risk.

Purpose of the Study:

  • To highlight the role of genetic predisposition in ovarian cancer risk.
  • To identify known hereditary syndromes associated with ovarian cancer.
  • To recommend management strategies for high-risk individuals.

Main Methods:

  • Review of established risk factors for ovarian cancer.
  • Identification and description of hereditary cancer syndromes linked to ovarian cancer.

Related Experiment Videos

  • Discussion of genetic linkage to BRCA1 on chromosome 17q for specific syndromes.

    • Main Results:

    • Genetic predisposition is a recognized strong risk factor for ovarian cancer.
    • Three hereditary syndromes are identified: breast-ovarian cancer syndrome, hereditary nonpolyposis colon cancer, and site-specific ovarian cancer.
    • Breast-ovarian and site-specific ovarian cancer syndromes are linked to the BRCA1 gene on chromosome 17q.

    Conclusions:

    • No simple genetic test currently identifies all women at high risk for ovarian cancer.
    • Genetic counseling, education, and surveillance are crucial for women with a family history of ovarian cancer.
    • Prophylactic oophorectomy may be considered for selected high-risk individuals.