Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thymus-neuroendocrine interactions in extrathymic T cell development

J Wang1, J R Klein

  • 1Department of Biological Science, University of Tulsa, OK 74104.

Science (New York, N.Y.)
|September 23, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Evidence of Solar Neutrino Interactions on ^{13}C.

Physical review letters·2026
Same author

Measurement of Reactor Antineutrino Oscillation at SNO.

Physical review letters·2025
Same author

Evidence of Antineutrinos from Distant Reactors Using Pure Water at SNO.

Physical review letters·2023
Same author

Roquin--a multifunctional regulator of immune homeostasis.

Genes and immunity·2015
Same author

Distribution of intravenously injected fructose and glucose between blood and brain.

Federation proceedings·2010
Same author

Distribution of intravenously injected fructose and glucose between blood and brain.

The Journal of biological chemistry·2010

Murine intestinal intraepithelial lymphocytes (IELs) development varies by experimental model. A neuroendocrine signal, likely from the thymus, is crucial for extrathymic maturation of gut alpha beta T cells.

Area of Science:

  • Immunology
  • Neuroendocrinology
  • Developmental Biology

Background:

  • Intraepithelial lymphocytes (IELs) are critical for gut immunity.
  • Studies on murine IEL development show conflicting results based on experimental systems.

Purpose of the Study:

  • To reconcile differing results in murine IEL development studies.
  • To investigate the role of neuroendocrine signals in IEL maturation.

Main Methods:

  • Comparison of IEL subsets in athymic radiation chimeras versus neonatally athymic adult mice.
  • Administration of thyrotropin-releasing hormone to neonatally thymectomized mice.

Main Results:

  • Athymic radiation chimeras possess diverse IEL subsets, similar to euthymic mice.

Related Experiment Videos

  • Neonatally athymic mice primarily exhibit T cell receptor gamma delta and CD8 alpha alpha IELs.
  • Thyrotropin-releasing hormone treatment restored normal IEL development in thymectomized mice.

    • Conclusions:

    • A thymus-initiated neuroendocrine signal is essential for extrathymic maturation of gut alpha beta T cells.
    • This finding clarifies discrepancies in IEL development research.