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Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
R Wooster1, S L Neuhausen, J Mangion
1Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK.
Science (New York, N.Y.)
|September 30, 1994
Abstract:
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.