Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salvage therapy for germ cell tumors

L H Einhorn1

  • 1Department of Medicine, Indiana University School of Medicine, Indianapolis.

Seminars in Oncology
|August 1, 1994
PubMed
Summary

Testicular cancer is highly curable, with chemotherapy offering significant success. Salvage therapies aim to cure patients with advanced disease using novel drug combinations and high-dose chemotherapy with bone marrow transplantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multidisciplinary clinic approach improves overall survival outcomes of patients with metastatic germ-cell tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Long-term toxicity of cisplatin in germ-cell tumor survivors.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Phase II trial of pembrolizumab in patients with platinum refractory germ-cell tumors: a Hoosier Cancer Research Network Study GU14-206.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Prognostic factors in patients with poor-risk germ-cell tumors: a retrospective analysis of the Indiana University experience from 1990 to 2014.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Utilization of sperm banking and barriers to its use in testicular cancer patients.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2015

Area of Science:

  • Oncology
  • Medical Chemotherapy

Background:

  • Testicular cancer is a highly curable neoplasm.
  • First-line chemotherapy, such as cisplatin/etoposide/bleomycin, cures approximately 70% of patients with disseminated disease.

Purpose of the Study:

  • To review salvage therapy strategies for testicular cancer.
  • To discuss the role of novel drug combinations and high-dose chemotherapy with autologous bone marrow transplantation in treating refractory testicular cancer.

Main Methods:

  • Review of salvage chemotherapy regimens.
  • Discussion of high-dose chemotherapy with autologous bone marrow transplantation.
  • Evaluation of autologous bone marrow transplantation as initial salvage therapy.

Main Results:

  • Second-line therapy with vinblastine/ifosfamide/cisplatin cures approximately 25% of patients.
  • High-dose chemotherapy with carboplatin and etoposide with autologous bone marrow transplantation cures 15% to 20% of patients with refractory disease.
  • Cure rates for extragonadal presentations remain low.

Conclusions:

  • Salvage therapy, utilizing active drugs not previously administered with cisplatin, can be curative.
  • High-dose chemotherapy with autologous bone marrow transplantation is a viable option for patients with refractory testicular cancer.
  • Further research is ongoing to optimize salvage strategies, including the use of autologous bone marrow transplantation as initial salvage therapy.

Related Experiment Videos