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Related Experiment Videos

Decorticate spasticity: a re-examination using quantitative assessment in the primate

R R Tasker, F Gentili, K Sogabe

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Researchers modeled decorticate spasticity in squirrel monkeys to test spasmolytic drugs. Bilateral ablation of the primary motor cortex induced spasticity, which was reduced by dentatectomy, offering insights into spasticity mechanisms.

    Area of Science:

    • Neuroscience
    • Primatology
    • Motor Control

    Background:

    • Spasticity is a common neurological condition.
    • Decorticate spasticity models are used to study muscle tone abnormalities.
    • Quantitative assessment of spasticity is crucial for evaluating treatments.

    Purpose of the Study:

    • To establish a quantitative model of decorticate spasticity in squirrel monkeys.
    • To evaluate the efficacy of clinical spasmolytic measures.
    • To investigate the role of cortical and cerebellar structures in spasticity.

    Main Methods:

    • Induction of cortical lesions (motor, premotor, parietal) unilaterally and bilaterally in squirrel monkeys.
    • Quantitative measurement of muscle tone using integrated electromyography (EMG).

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  • Stereotactic dentatectomy and assessment of its effects on spasticity.

    • Main Results:

    • Bilateral ablation of the primary motor cortex reliably induced measurable spasticity, primarily affecting biceps brachii and quadriceps.
    • The evoked EMG response was proportional to the rate of stretch, similar to human hemiplegic spasticity.
    • Stereotactic dentatectomy significantly reduced ipsilateral spasticity.

    Conclusions:

    • Bilateral primary motor cortex ablation is effective in creating a quantifiable model of spasticity.
    • The cerebellum, specifically the dentate nucleus, plays a role in modulating spasticity.
    • The study provides a basis for evaluating spasmolytic interventions in a controlled model.