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[Is selection for extended life expectancy possible by regularity in aging?]

H Niedermüller1, G Hofecker

  • 1Institut für Physiologie, Veterinärmedizinische Universität Wien.

Zeitschrift Fur Gerontologie
|May 1, 1994
PubMed
Summary

Later evolving species exhibit longer maximum life spans (MLP) due to enhanced antibiosenescent strategies (AS). This suggests aging is a regular, predictable physiological process, not solely programmed.

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Area of Science:

  • Evolutionary biology
  • Gerontology
  • Physiology

Context:

  • Species evolving later in evolutionary history generally possess higher maximum life span potentials (MLP).
  • The aging process is a regular physiological event, amenable to explanation and prediction through experimental gerontology.
  • Existing research explores genetic, metabolic, and repair mechanisms influencing biological aging.

Purpose:

  • To explain the evolutionary development of maximum life span potentials (MLP).
  • To evaluate two primary hypotheses for the causes of aging: programmed aging (adaptive hypothesis) versus error accumulation (nonadaptive hypotheses, e.g., disposable soma).
  • To determine whether aging is a programmed event or a consequence of accumulated damage.

Summary:

  • Later-evolving species demonstrate increased MLP, correlating with enhanced antibiosenescent strategies (AS).

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  • This supports the nonadaptive hypothesis, suggesting species invest more in somatic maintenance (AS) when better adapted to environments with fewer risks.
  • Aging is viewed as a regular physiological process influenced by evolutionary adaptations in somatic maintenance and repair mechanisms.

    • Impact:

    • Provides insights into the evolutionary drivers of aging and lifespan variation across species.
    • Contributes to understanding the biological basis of aging, potentially informing strategies for healthspan extension.
    • Highlights the role of environmental adaptation and resource allocation (soma vs. reproduction) in shaping aging processes.