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Pulmonary aspergillosis: imaging findings with pathologic correlation

S L Aquino1, S T Kee, M L Warnock

  • 1Department of Radiology, University of California, San Francisco 94143-0628.

AJR. American Journal of Roentgenology
|October 1, 1994
PubMed
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Pulmonary aspergillosis from Aspergillus fumigatus presents diversely based on immune status. This review correlates radiologic findings with pathology for various forms, including allergic bronchopulmonary aspergillosis (ABPA) and invasive disease.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Radiology

Background:

  • Pulmonary involvement by Aspergillus fumigatus varies significantly with patient immune and lung health.
  • Inhalation of Aspergillus spores can trigger hypersensitivity reactions like acute allergic alveolitis.
  • Bronchial colonization leads to allergic bronchopulmonary aspergillosis (ABPA), primarily in asthma and cystic fibrosis patients.

Purpose of the Study:

  • To illustrate the diverse radiologic findings associated with pulmonary aspergillosis.
  • To correlate imaging findings with pathological characteristics of the disease.
  • To provide a comprehensive overview of Aspergillus-related lung conditions.

Main Methods:

  • Review of radiologic findings in pulmonary aspergillosis.

Related Experiment Videos

  • Correlation of imaging features with histopathological data.
  • Discussion of different clinical presentations: hypersensitivity, ABPA, mycetomas, invasive aspergillosis.

    • Main Results:

    • Radiologic findings differ based on the type of pulmonary aspergillosis.
    • Imaging can help differentiate between hypersensitivity reactions, ABPA, mycetomas, and invasive forms.
    • Pathological confirmation is crucial for definitive diagnosis.

    Conclusions:

    • Pulmonary aspergillosis has varied manifestations dependent on host factors.
    • Radiology plays a key role in identifying and characterizing pulmonary Aspergillus infections.
    • Understanding the imaging-pathology correlation aids in diagnosis and management.