Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Editorial: Considerations of risks versus benefits

H L Falk

    Environmental Health Perspectives
    |June 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Encourage risk-benefit evaluations for new products, even those with potential carcinogens or teratogens, as safety thresholds likely exist. Comparing future risks and benefits across generations remains a significant challenge.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Practice guidelines for management of infant and children with fever without source (FWS)

    Pediatrics·1994
    Same author

    Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.

    Environmental health perspectives·1982
    Same author

    Renal tumors in rats given trisodium nitrilotriacetic acid in drinking water for 2 years.

    Journal of the National Cancer Institute·1981
    Same author

    Extrapolating carcinogenesis data from animals to humans.

    Federation proceedings·1980
    Same author

    Health effects of coal mining and combustion: carcinogens and cofactors.

    Environmental health perspectives·1979
    Same author

    Surveillance for future environmental contaminants: discussion.

    Annals of the New York Academy of Sciences·1979
    Same journal

    A New Start.

    Environmental health perspectives·2026
    Same journal

    Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

    Environmental health perspectives·2026
    Same journal

    Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

    Environmental health perspectives·2026
    Same journal

    Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

    Environmental health perspectives·2026
    Same journal

    Workflow for Statistical Analysis of Environmental Mixtures.

    Environmental health perspectives·2026
    Same journal

    Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

    Environmental health perspectives·2026
    See all related articles

    Area of Science:

    • Toxicology
    • Risk Assessment
    • Public Health Policy

    Background:

    • Assessing new products requires balancing potential risks against benefits.
    • Concerns exist regarding agents causing cancer or malformations in laboratory animals.
    • Evidence suggests that safety thresholds may exist for hazardous exposures.

    Purpose of the Study:

    • To advocate for the evaluation of risks versus benefits of new products.
    • To address the challenges in comparing risks and benefits involving future generations.

    Main Methods:

    • Review of existing toxicological data and risk assessment principles.
    • Analysis of the complexities in quantifying long-term and intergenerational impacts.
    • Discussion of policy implications for product safety evaluations.

    Related Experiment Videos

    Main Results:

    • Risk-benefit analysis is encouraged even for agents with known hazards.
    • The existence of safety thresholds provides a basis for such evaluations.
    • Quantifying and comparing risks and benefits across future generations is inherently difficult.

    Conclusions:

    • Risk-benefit assessments are crucial for new product development and regulation.
    • The principle of safety thresholds supports continued evaluation of potentially hazardous agents.
    • Further research is needed to develop methodologies for assessing long-term and intergenerational risks and benefits.