Related Experiment Videos
Genetic control of polyketide biosynthesis in the genus Streptomyces
C R Hutchinson1, H Decker, K Madduri
1School of Pharmacy, University of Wisconsin, Madison 53706.
Antonie Van Leeuwenhoek
|January 1, 1993
Abstract:
The genetic control of polyketide metabolite biosynthesis in Streptomyces sp. producing actinorhodin, daunorubicin, erythromycin, spiramycin, tetracenomycin and tylosin is reviewed. Several examples of positively-acting transcriptional regulators of polyketide metabolism are known, including some two-component sensor kinase-response regulator systems. Translational and posttranslational control mechanisms are only briefly mentioned since very little is known about either of these processes. Examples of how enzyme levels and substrate supply affect polyketide metabolism also are discussed.