Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimal therapy for stress gastritis

R V Maier1, D Mitchell, L Gentilello

  • 1Department of Surgery, Harborview Medical Center, University of Washington, Seattle.

Annals of Surgery
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The attribution of human health outcomes to climate change: a transdisciplinary guidance document.

Climatic change·2025
Same author

Systematic Implementation of Effective Quality Assurance Processes for the Assessment of Radiation Target Volumes in Head and Neck Cancer.

Practical radiation oncology·2024
Same author

Stability of retinol in liposomes as measured by fluorescence lifetime spectroscopy and FLIM.

BBA advances·2023
Same author

Psychopathology and eating behaviour in people with type 2 diabetes referred for bariatric surgery.

Eating and weight disorders : EWD·2022
Same author

Exploring utilisation of the allied health assistant workforce in the Victorian health, aged care and disability sectors.

BMC health services research·2021
Same author

Eight new <i>Elaphomyces</i> species (<i>Elaphomycetaceae, Eurotiales, Ascomycota</i>) from eastern North America.

Fungal systematics and evolution·2021

Sucralfate is as effective as H2 blockers for preventing stress ulcers in critically ill patients. It may also reduce pneumonia rates and significantly cut healthcare costs.

Area of Science:

  • Critical Care Medicine
  • Gastroenterology
  • Pharmacology

Background:

  • Stress ulceration is a significant cause of morbidity and mortality in critically ill patients.
  • Gastric acid neutralization is a common prophylactic measure, but its effect on nosocomial pneumonia is debated.
  • The comparative efficacy and cost-effectiveness of sucralfate versus H2 blockers for stress ulcer prophylaxis remain unclear.

Purpose of the Study:

  • To compare the efficacy of sucralfate versus H2 blockers (with antacids) for stress ulcer prophylaxis in intensive care unit (ICU) patients.
  • To evaluate the impact of each treatment on the incidence of nosocomial pneumonia.
  • To analyze the financial implications of each prophylactic approach.

Main Methods:

  • A randomized trial involving 98 critically ill, intubated patients requiring ICU support for at least 72 hours.

Related Experiment Videos

  • Patients received either continuous H2 blocker infusion (ranitidine) plus antacids or sucralfate via nasogastric tube.
  • Outcomes measured included stress ulcer complications, nosocomial pneumonia rates, ventilator days, ICU length of stay, and hospital length of stay.

    • Main Results:

    • Both treatments were effective in preventing major bleeding, with only one patient in each group requiring transfusion.
    • The incidence of nosocomial pneumonia was slightly lower in the sucralfate group (20.8%) compared to the H2 blocker group (27.5%), though not statistically significant (p=0.48).
    • Patients receiving sucralfate had shorter ICU stays (10.2 vs 14.7 days) and hospital stays (20.0 vs 27.8 days), with significant cost savings of over $30,000 per ICU bed annually.

    Conclusions:

    • Sucralfate is as effective as maximal H2 blocker therapy for preventing stress ulceration in critically ill patients.
    • Sucralfate may offer a potential benefit in reducing the incidence of nosocomial pneumonia.
    • Sucralfate prophylaxis is associated with reduced nursing requirements and significant cost savings compared to H2 blockers.