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Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Regulation of Stroke Volume01:27

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neural Regulation01:37

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

Updated: Jan 4, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

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The neuropathology of stroke

J H Garcia

    Human Pathology
    |September 1, 1975
    PubMed
    Summary

    Central nervous system damage can stem from vascular issues causing brain lesions. These lesions, whether hemorrhagic or ischemic, are linked to conditions like hypertension and arterial occlusion.

    Area of Science:

    • Neurology
    • Pathology
    • Vascular Biology

    Background:

    • Vascular-circulatory derangements can cause central nervous system (CNS) parenchymal lesions.
    • These lesions manifest as hemorrhagic, ischemic, or mixed types.
    • Hypertensive disease is frequently associated with nontraumatic intraparenchymal brain hemorrhages.

    Purpose of the Study:

    • To describe the types and characteristics of CNS parenchymal lesions resulting from vascular-circulatory derangements.
    • To detail the evolution of ischemic brain injury following arterial occlusion.

    Main Methods:

    • Review of pathological findings in CNS lesions associated with vascular diseases.
    • Description of morphological changes in different types of ischemia (global and regional).

    More Related Videos

    A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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    Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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    Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

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    Related Experiment Videos

    Last Updated: Jan 4, 2026

    A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
    08:36

    A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

    Published on: March 17, 2016

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    A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
    06:01

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    Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
    08:22

    Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

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    Main Results:

    • Hypertensive disease is linked to brain hemorrhages, often with cardiac and renal changes.
    • Global ischemia from hypotension causes varied, potentially widespread lesions.
    • Regional ischemia from arterial occlusion progresses through stages: acute encephalomalacia, inflammation, and resolution, with specific neuronal and glial changes.

    Conclusions:

    • Vascular pathology significantly impacts CNS structure, leading to diverse lesion types.
    • Understanding the evolution of ischemic injury is crucial for diagnosing and managing cerebrovascular diseases.
    • Early cellular changes in ischemia involve mitochondrial swelling and selective astrocyte/neurite swelling.