Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

230
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
230
Self-Evaluation Maintenance Model01:29

Self-Evaluation Maintenance Model

294
The Self-Evaluation Maintenance (SEM) model offers a psychological framework to understand how individuals’ self-esteem is influenced by the achievements of others, particularly those with whom they share close personal bonds. The SEM model operates when personal rather than social identity guides individuals. Central to this model is the notion that individuals have an inherent desire to preserve a favorable self-image, which is continuously shaped by interpersonal comparisons and...
294
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

2.7K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.7K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.9K
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

5.4K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
5.4K
Energy Budgets00:51

Energy Budgets

10.7K
Organisms must balance energy intake with the energy required for growth, maintenance and reproduction. These trade-offs result in a variety of survivorship and reproductive strategies, including semelparity and iteroparity. Semelparous species, like annual plants, have only one reproductive episode in their lifetimes and consequently have short lifespans. Iteroparous species, by contrast, have many reproductive events during their lifetimes but have relatively few offspring. These two...
10.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Effect of systemic autonomic inhibition on the hemodynamic response to antihypertensive therapy with timolol.

International journal of clinical pharmacology and biopharmacy·1979
Same journal

Treatment of hyperlipoproteinemia (HLP) type II A with a new phenoxy-isobuturic acid derivative, procetofen.

International journal of clinical pharmacology and biopharmacy·1979
Same journal

Treatment of hyperlipoproteinemia type II with etofibrate.

International journal of clinical pharmacology and biopharmacy·1979
Same journal

In vitro and in vivo characteristics of some commercial phenobarbital tablets.

International journal of clinical pharmacology and biopharmacy·1979
Same journal

Pharmacokinetics of naproxen in healthy volunteers and in patients with diabetic microangiopathy.

International journal of clinical pharmacology and biopharmacy·1979
Same journal

Appropriate nitroxoline dosage regimen design.

International journal of clinical pharmacology and biopharmacy·1979
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

Creation and Maintenance of a Living Biobank - How We Do It
13:08

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

8.1K

Methadone maintenance

W J Russell-Taylor

    International Journal of Clinical Pharmacology and Biopharmacy
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Methadone maintenance for heroin addiction is controversial and costly. New data suggest some patients might fare better without this narcotic substitution therapy, questioning its overall effectiveness.

    More Related Videos

    Reducing State Anxiety Using Working Memory Maintenance
    08:17

    Reducing State Anxiety Using Working Memory Maintenance

    Published on: July 19, 2017

    8.1K
    Maintenance of a Drosophila melanogaster Population Cage
    08:03

    Maintenance of a Drosophila melanogaster Population Cage

    Published on: March 15, 2016

    13.9K

    Related Experiment Videos

    Last Updated: Jan 24, 2026

    Creation and Maintenance of a Living Biobank - How We Do It
    13:08

    Creation and Maintenance of a Living Biobank - How We Do It

    Published on: April 10, 2021

    8.1K
    Reducing State Anxiety Using Working Memory Maintenance
    08:17

    Reducing State Anxiety Using Working Memory Maintenance

    Published on: July 19, 2017

    8.1K
    Maintenance of a Drosophila melanogaster Population Cage
    08:03

    Maintenance of a Drosophila melanogaster Population Cage

    Published on: March 15, 2016

    13.9K

    Area of Science:

    • Pharmacology
    • Addiction Medicine
    • Public Health Policy

    Background:

    • Oral methadone maintenance is a widely adopted treatment for heroin addiction, despite ongoing controversy.
    • Significant public funds are allocated to methadone programs across North America, with expenditures reaching hundreds of millions annually.
    • Concerns exist regarding the lack of objective data substantiating the efficacy of methadone maintenance as a narcotic substitution therapy.

    Purpose of the Study:

    • To critically evaluate the methadone maintenance approach for heroin addiction.
    • To assess the iatrogenic consequences and overall worth of narcotic substitution therapy.
    • To present data suggesting alternative management strategies may be more beneficial for some patients.

    Main Methods:

    • Review of existing data on methadone maintenance programs.
    • Analysis of patient outcomes from Philadelphia General Hospital.
    • Critical evaluation of pharmacological and clinical evidence.

    Main Results:

    • Objective data supporting methadone maintenance therapy remain limited.
    • Increasing iatrogenic consequences and growing skepticism among pharmacologists are noted.
    • Preliminary data indicate that some patients may have been better managed without methadone.

    Conclusions:

    • A critical re-evaluation of methadone maintenance therapy is warranted.
    • The effectiveness and long-term benefits of narcotic substitution therapy require further objective investigation.
    • Alternative or individualized treatment approaches may be necessary for optimal heroin addiction management.